Materials and methods: Effect of an extract of Andrographis paniculata leaves (AP) was studied on inhibition
of LPS induced NO, PGE2, IL-1 beta and IL-6 in J774A.1 murine macrophages; A23187 induced LTB4 and
TXB2 in HL-60 promyelocytic leukemic cells and histamine in RBL-2H3 rat basophilic leukemia cells.
Results and conclusion: AP illustrated significant alleviation of pro-inflammatory, inflammatory, and
allergic mediators. However, no inhibition was observed against histamine release. This outcome has
been summed up to deduce that AP is fairly potent in attenuating the inflammation by inhibiting proinflammatory
(NO, IL-1 beta and IL-6), inflammatory (PGE2 and TXB2) and allergic (LTB4) mediators.