Polyostotic fibrous dysplasia is a systemic
syndrome in which diffuse bony lesions of
fibrous dysplasia involve multiple areas of the
skeleton. The McCune-Albright syndrome
includes polyostotic fibrous dysplasia, café-au-lait
melanotic macules, and endocrine abnormalities,
such as precocious puberty in females. The
Jaffe-Lichtenstein syndrome includes
polyostotic fibrous dysplasia plus café-au-lait
pigmentation without endocrine abnormalities.