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1. The Story
Most likely, the events of Spider-Man: Homecoming will take place after Peter is introduced in Captain America: Civil War. In that movie, Tony Stark recruits Peter into the action of Civil War and helps him design his suit, although Peter will still be in high school. But it will not cover his entire origin story with the bite by a radioactive spider leading to his powers since that has been covered multiple times in the other Spiderman movies. Besides Tony Stark, other Marvel heroes like Captain America and Doctor Strange might swing through this movie.
2. The Villain
Every superhero movie needs a main villain for our hero to defeat, and the rumor is that it might be The Vulture. The main reason for this is that Marvel and Sony wanted to stay away from villains that already appeared in previous movies. Removing Doctor Octopus, Sandman, Venom, the Green Goblin and Electro from the list. It’s likely that Vulture would be the main villain in Spider-Man: Homecoming. But hopefully, we’ll meet another villain as an opening scene villain to show us what we can expect from Spiderman.