Weight loss with dapagliflozin was progressive during the first 6 months and stabilizedduringthelatterhalfofthestudy. This may have resulted from glucosuriainduced fat loss, fluid loss associated with osmoticdiuresis,oracombinationofboth. Studiesofbodycompositionareunderway to assess the relative contributions of fat and fluid loss to the changes in TBW observed with dapagliflozin.