In recent years, engineering the total morphology of pharmaceutical materials particles to
desirable shape, size and surface area has long been actively increased because it has
many advantages especially for improving physicochemical properties of Active Pharmaceutical
Ingredients (APIs). This article therefore considers the potential utility of crystal
engineering as a tool for controlling and designing properties of pharmaceutical solid
particles in purpose to developing efficacious performance of solid dosage form, fundamentals
of crystallization process, applications. In addition, understanding the relationship
between molecular recognition, thermodynamic, and kinetics which controls the
crystallization process so that it benefits in designing successful experiments to have
desirable crystal habit for materials.
© 2015 Shenyang Pharmaceutical University. Production and hosting by Elsevier B.V. This is
an open access article under the CC BY-NC-ND license (http://creativecommons.org/
licenses/by-nc-nd/4.0/).