Anesthetic solution reaches the periapical tissues by diffusing apically into the marrow spaces surrounding the teeth into the interseptal bone
Solution does not course through the actual PDL to the apex
#1 post-operative complication is the complaint by the patient of pain when chewing for 2-3 days following the PDL injection
Pressure syringes can produce too much pressure leading to sloughing papilla
Conventional syringes are equally effective in producing PDL anesthesia
Slow injection make the PDL injection less traumatic