Important festivals in the province include the traditional dances of the Phu Thai ethnic group held during May and June every year. The Phra That Phanom temple fair is held every February, when many locals pilgrim to the temple to pay homage. At the end of the Buddhist Lent in November, an illuminated boat procession takes place.
The cuisine is similar to that of Isan. Pla ra, fermented, preserved fish, originally comes from the Si Songkhram area is now popular throughout Thailand.
Traditional products in the province include hand-woven fabric, made from silk or cotton. Renu Nakhon, That Phanom and Si Songkhram districts are the centers of this industry. Also hand-made Kaen instruments can be found in the province.