Hemoglobin (Hb) is an important protein in red blood cells
because of their ability to transport oxygen in mammalian blood.
The determination of Hb is one of the most important measurements
required in clinical analysis since it is involved in many
diseases such as thalassemia, anemia, leukemia, heart disease, and
excessive loss of blood [1–4]. In addition to Hb, which contains a
four iron protoporphyrin or heme moiety, there are other heme
proteins that involve with oxygen transport. One of the most interesting
heme proteins is myoglobin (Mb), mainly found in heart and
skeletal muscles [5] and serves as an intracellular storage site for
oxygen. High Mb concentrations in serum and urine may be caused
by muscle cramps, excessive exercise, trauma, the toxin from sea
snake bite and myocardial infarction [6,7]. Interestingly, Mb is the
most sensitive marker for myocardial injury because it is the first
marker released after damage to myocardial muscle cells [8,9].
Thus, the diagnostic sensitivity of Mb can be very useful in clinical
use.
Hemoglobin (Hb) is an important protein in red blood cellsbecause of their ability to transport oxygen in mammalian blood.The determination of Hb is one of the most important measurementsrequired in clinical analysis since it is involved in manydiseases such as thalassemia, anemia, leukemia, heart disease, andexcessive loss of blood [1–4]. In addition to Hb, which contains afour iron protoporphyrin or heme moiety, there are other hemeproteins that involve with oxygen transport. One of the most interestingheme proteins is myoglobin (Mb), mainly found in heart andskeletal muscles [5] and serves as an intracellular storage site foroxygen. High Mb concentrations in serum and urine may be causedby muscle cramps, excessive exercise, trauma, the toxin from seasnake bite and myocardial infarction [6,7]. Interestingly, Mb is themost sensitive marker for myocardial injury because it is the firstmarker released after damage to myocardial muscle cells [8,9].Thus, the diagnostic sensitivity of Mb can be very useful in clinicaluse.
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