Health and Safety management in research laboratory has been developed according to the standard practice. To evaluate the implementation of the Health and Safety management in research laboratory, 8 pilot research laboratories in department of chemistry, faculty of science. The developed system consists of 3 main parts including 1) Chemical and hazardous waste management 2) Safety management by safety training and by proper safety equipments and personal protective equipment (PPE) providing 3) Safety audit and Risk assessment. Assessment evaluation has been done on 8 pilot research laboratories by the Safety Committee and Safety management division, Energy Environment Safety and Health (EESH) Office.