viability and proliferation of immune cells inhibiting protein biosynthesis and altering the pro-inflammatory cytokine production. DON binds to peptidyl transferase inhibiting the synthesis of RNA and DNA and modifying cell membranes . reported that the ingestion of contaminated wheat by Pekin ducks decreased the mass of the bursa of Fabricius with consequent reduction of antibody production. Other studies reported that low concentrations of DON (less than
5 mg/kg feed) stimulated the immune system while high concentrations suppressed the immune responses (Pestka, 2003).