Clinical course Clinical course of dengue fever[10] The characteristic symptoms of dengue are sudden-onset fever, headache (typically located behind the eyes), muscle and joint pains, and a rash. The alternative name for dengue, "breakbone fever", comes from the associated muscle and joint pains.[2][11] The course of infection is divided into three phases: febrile, critical, and recovery.[10] The febrile phase involves high fever, potentially over 40 °C (104 °F), and is associated with generalized pain and a headache; this usually lasts two to seven days.[10][11] Nausea and vomiting may also occur.[9] A rash occurs in 50–80% of those with symptoms[11][12] in the first or second day of symptoms as flushed skin, or later in the course of illness (days 4–7), as a measles-like rash.[12][13] A rash described as "islands of white in a sea of red" has also been observed.[14] Some petechiae (small red spots that do not disappear when the skin is pressed, which are caused by broken capillaries) can appear at this point,[10] as may some mild bleeding from the mucous membranes of the mouth and nose.[7][11] The fever itself is classically biphasic or saddleback in nature, breaking and then returning for one or two days.[13][14] The rash of dengue fever in the acute stage of the infection blanches when pressed In some people, the disease proceeds to a critical phase as fever resolves.[9] During this period, there is leakage of plasma from the blood vessels, typically lasting one to two days.[10] This may result in fluid accumulation in the chest and abdominal cavity as well as depletion of fluid from the circulation and decreased blood supply to vital organs.[10] There may also be organ dysfunction and severe bleeding, typically from the gastrointestinal tract.[7][10] Shock (dengue shock syndrome) and hemorrhage (dengue hemorrhagic fever) occur in less than 5% of all cases of dengue,[7] however those who have previously been infected with other serotypes of dengue virus ("secondary infection") are at an increased risk.[7][15] This critical phase, while rare, occurs relatively more commonly in children and young adults.[9] The rash that commonly forms during the recovery from dengue fever with its classic islands of white in a sea of red. The recovery phase occurs next, with resorption of the leaked fluid into the bloodstream.[10] This usually lasts two to three days.[7] The improvement is often striking, and can be accompanied with severe itching and a slow heart rate.[7][10] Another rash may occur with either amaculopapular or a vasculitic appearance, which is followed by peeling of the skin.[9] During this stage, a fluid overload state may occur; if it affects the brain, it may cause a reduced level of consciousness or seizures.[7] A feeling of fatigue may last for weeks in adults.[9]
Clinical course Clinical course of dengue fever[10] The characteristic symptoms of dengue are sudden-onset fever, headache (typically located behind the eyes), muscle and joint pains, and a rash. The alternative name for dengue, "breakbone fever", comes from the associated muscle and joint pains.[2][11] The course of infection is divided into three phases: febrile, critical, and recovery.[10] The febrile phase involves high fever, potentially over 40 °C (104 °F), and is associated with generalized pain and a headache; this usually lasts two to seven days.[10][11] Nausea and vomiting may also occur.[9] A rash occurs in 50–80% of those with symptoms[11][12] in the first or second day of symptoms as flushed skin, or later in the course of illness (days 4–7), as a measles-like rash.[12][13] A rash described as "islands of white in a sea of red" has also been observed.[14] Some petechiae (small red spots that do not disappear when the skin is pressed, which are caused by broken capillaries) can appear at this point,[10] as may some mild bleeding from the mucous membranes of the mouth and nose.[7][11] The fever itself is classically biphasic or saddleback in nature, breaking and then returning for one or two days.[13][14] The rash of dengue fever in the acute stage of the infection blanches when pressed In some people, the disease proceeds to a critical phase as fever resolves.[9] During this period, there is leakage of plasma from the blood vessels, typically lasting one to two days.[10] This may result in fluid accumulation in the chest and abdominal cavity as well as depletion of fluid from the circulation and decreased blood supply to vital organs.[10] There may also be organ dysfunction and severe bleeding, typically from the gastrointestinal tract.[7][10] Shock (dengue shock syndrome) and hemorrhage (dengue hemorrhagic fever) occur in less than 5% of all cases of dengue,[7] however those who have previously been infected with other serotypes of dengue virus ("secondary infection") are at an increased risk.[7][15] This critical phase, while rare, occurs relatively more commonly in children and young adults.[9] The rash that commonly forms during the recovery from dengue fever with its classic islands of white in a sea of red. The recovery phase occurs next, with resorption of the leaked fluid into the bloodstream.[10] This usually lasts two to three days.[7] The improvement is often striking, and can be accompanied with severe itching and a slow heart rate.[7][10] Another rash may occur with either amaculopapular or a vasculitic appearance, which is followed by peeling of the skin.[9] During this stage, a fluid overload state may occur; if it affects the brain, it may cause a reduced level of consciousness or seizures.[7] A feeling of fatigue may last for weeks in adults.[9]
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