Self-efficacy and goal orientation are important variables which affect student learning behaviour. To investigate the relationship between these variables and their effect on learning behaviour over time, a pretest–posttest non-equivalent group design with three repeated measures was used. During an 8-week period, student self-efficacy, goal orientation, and learning behaviour were measured using validated questionnaires among first-year higher education, mixed-nationality (Dutch and German) students in a problem- based learning context. Goal orientations were significantly related to deep learning, and self-efficacy was significantly related to a specific goal orientation, namely the mastery- approach. Mastery goal orientations decreased over time, while the surface learning behaviour increased. Significant differences were found between nationalities with respect to learning behaviour and goal orientation.