Background Tretinoin is considered the benchmark prescription topical therapy for
improving fine facial wrinkles, but skin tolerance issues can affect patient compliance.
In contrast, cosmetic antiwrinkle products are well tolerated but are generally
presumed to be less efficacious than tretinoin.
Objectives To compare the efficacy of a cosmetic moisturizer regimen vs. a prescription
regimen with 0Æ02% tretinoin for improving the appearance of facial
wrinkles