DISCUSSION
Pre-eclampsia (PE) remains to be one of the
primary cause of maternal and fetal morbidity and
11 mortality all over the world . This is the reason that
about 10-12% of pregnant women in our
population suffered from hypertensive disorder.
Severe hypertension in a pregnant woman is a
multisystem disease and a threat to the well- being
12 of both mother and child . Most studies showed
that, this increased risk mainly occurs among
women with severe chronic hypertension in those
13 who develop superimposed preeclampsia .
Regarding platelet count which is the main tool of
early detection of thrombocytopenia in women
with pregnancy-induced hypertension, it has been
observed that platelet count was significantly
found lower in PIH women when compared with
normal pregnant women. This significantly
reduced platelet count in preeclampsia has also
been reported by other researchers.
A study conducted in India showed that platelet
count in pre-eclampsic group and eclampsic
group showed significantly decreased platelet
count when compared with the normotensive
14 control group . Another study conducted at
Turkey also showed lower platelet count in severe
15 pre-eclampsic women (p<0.05) .
Similarly when the value of platelet count between
the control and study groups were compared
significant reduction in platelet count was
observed, this shows that most of the women with
eclampsia have very low platelet count as
16 compared to mild and severe preeclampsia . It
has also been reported that the mean value of
platelet counts were significantly decreased in the
pre-eclamptic patients than normotensive
17 pregnant women . The present study also
showed that there is no statistically significant
difference found between platelet count in mild
and severe preeclampsia, thus confirming with the
18 result of others researchersl .
Some other researchers also reported that during
p r e g n a n c y, t h e c o m m o n e s t c a u s e o f
thrombocytopenia are gestational thrombocyto-
19,20 penia, preeclampsia and eclampsia . It has
been observed and reported that about 6.6-11.6%
21 of pregnancies results in thrombocytopenia . The
h y p o t h e s i s r e g a r d i n g p a t h o g e n e s i s o f
thrombocytopenia in preeclampsia is still not clear,
but in this connection some researcher reported
that thrombocytopenia is caused due to the
involvement of endothelial damage and peripheral
22 consumption . It is also found that in pregnancies
complicated with preeclampsia, the life span of
platelet is reduced from 3 to 5 days and the altered
platelet membrane accelerates its aggregation
23 and destruction . The findings are almost in line
with the present results and investigation.
CONCLUSIONS
The results of this study conclude that a better
control on systolic and diastolic pressure is
needed in women with pregnancy-induced
hypertension. Also platelets count was performed
and found that a significant decrease in platelet
number was observed in women with pregnancy
induced hypertension when compared with
normotensive pregnant women. This shows that
there is a direct relationship of platelet count and
severity of preeclampsia and eclampsia.
Therefore early detection of platelet count can be
useful and beneficial as screening test for the
assessment of severity of preeclampsia and
eclampsia as it is rapid and cheaper technique.
การแปล กรุณารอสักครู่..
