The antagonism of Bothrops jararacussu and Bothrops
jararaca pro-clotting activities in vitro may be directly related
to the inhibition of “thrombin-like” enzymes from the venom that
produce high levels of fibrin, inducing fibrinogen depletionand
leading to the hemorrhagic process.In agreement with this
hypothesis are the results obtained with the inhibition of different
proteolytic enzymes such as caseinolytic enzyme from Bothrops
jararacussu venom, collagenase from bacteria,and Bothrops venom
collagenase activities.It is possible that compounds in the
Combretum leprosum extract in hibit the different enzyme activities
and/or the pharmacological sites of action of the setoxins