RCTs WITH A PLACEBO CONTROL
Twelve of the 14 placebo-controlled studies found that
IV acetaminophen patients had improved analgesia. Ten
of the 14 placebo-controlled studies found either a significant
reduction in mean opioid consumption or a
lower percentage of patients rescuing with IV acetaminophen.
One study that had no observed pain difference
found that IV acetaminophen patients did need less
rescue compared with placebo patients.