The aqueous suspension of 70% alcoholic extract of Ocimum sanctum L. was investigated
for antifatigue activity in rats. Swimming time, change in body weight, lipid peroxidation,
Lactic Acid (LA), glycogen and blood biochemical parameters namely heamoglobin (Hb%),
Blood Urea Nitrogen (BUN) and Creatine Kinase (CK) were evaluated as biomarkers of
physical fatigue. Leaf extract of O. sanctum at 300 mg kg-1 b. wt would be the optimum
concentration to act against fatigue in rats [48]. Treatment at 300 mg kg-1 b.wt. facilitated the
aerobic glucose metabolism and promote swimming time, suggesting that O. sanctum
ameliorates the various impairments associated with physical fatigue. Furthermore validation
is needed regarding the optimal concentration.