The remarkable difference of the alkaloidal patterns in A. scholaris in different ecological environments has been reported in 1990 [14]. Moreover, we found that plant secondary metabolites would be influenced significantly by the ecological environment [15]. Then, we investigated HPLC fingerprints of alkaloids of A. scholaris from Pu'er and Kunming, and the result exhibited visible difference, which encouraged us to search for structurally unique and biologically active indole alkaloids of A. scholaris from different climate zones. As a result, three new monoterpenoid indole alkaloids,