For Candida spp., MICs of CLEO ranged 15.6–31.2 mg/mL,
and minimum fungicidal concentrations (MFCs) 31.2–62.5 mg/
mL, while the active fraction had higher MIC and MFC values,
ranging from 31.2 mg/mL to 250 mg/mL and 125 mg/mL to
1000 mg/mL, respectively, indicating a synergistic activity of the
EO components (mono- and sesquiterpene hydrocarbons) as
their isolation into fractions led to a decreased antimicrobial
effect, and hence C. sativum EO can be used as a potential
candidate in the treatment of oral diseases, such as denturerelated
candidiasis [34].