The spongy polysaccharide film used in this study contained no medication and it worked just as mechanical barrier. This study is important because it proved the permanence of the polysaccharide film in ulcer at D3 and D7, justifying the dressing as a mechanical barrier. As there is the possibility to add drugs in the polysaccharide sponges it can also be used as a drug-releasing system. Relating to this study we also must consider that rabbits are ruminants, which increases the mechanical effect of mastication. This fact is extremely important considering that a major problem for the symptomatic treatment of the aphthous stomatitis is to fix the drug long enough. Dilution with saliva, the chewing movements and the speech are factors which turn very difficult the use of an effective substance for long enough in the oral mucosa. Another advantage of the spongy polysaccharide film is that it allows the incorporation of many drugs in their composition which can further accelerate the healing and pain relief, considering that this is what most affects the quality of life of patients.