scaffolds have limited the use of calcium phosphate-based compounds as the bone scaffold materials for
clinical application. In addition to being biodegradable, biocompatible, osteoconductive, and bioactive, scaffolding materials used for bone implantation must be mechanically matched to nature bone. This requirement has lead to the biocompositing of the calcium phosphate with polymers (synthesized polymer such as PCL, PMMA, PLA or
biopolymers such as chitosan, collagen and alginate are widely used) to improve their mechanical properties [11–16].