Enterokinase (cleavage site DDDDK:), Factor Xa (cleavage site IEGR:), SUMO protease (recognizes SUMO tertiary structure and cleaves at the C-terminal end of the conserved Gly–Gly sequence in SUMO), Thrombin (cleavage site LVPR:GS) are the common proteases used to remove tags often from recombinant protein (Table 1).