Stem Cell Research
Highlights
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Oxidative stress induces autophagy in BMSCs.
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Vitamin C rescued the BMSCs from oxidative stress by regulating autophagy markers.
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Knockdown of the SVCT2 transporter in BMSCs dramatically decreased cell survival.
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SVCT2 knockdown BMSCs showed compromised autophagic flux.
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SVCT2 plays a vital role in the BMSC survival under stress conditions.