All the substrate samples colonized quickly (15-16 days) and time for pinning varied between 18 and 24 days. The P. pulmonarius strains produced three flushes within 47 days (starting from inoculation) and the P. ostreatus strains needed 57-63 days completing flush 3. Biological efficiencies after 3 flushes varied between 38% and 100%. The effect of bran supplementation on yields depended on the concentration (0, 1, 6 and 12% w/w), type of bran (rice or wheat) and strain used. The trials have shown that cassava waste (stems and peels) can be used well for the production of oyster mushrooms and that substrates containing up to 75% cassava peels have productions well comparable to yields obtained on the traditional saw dust based substrates.