Inductively coupled plasma mass spectrometry (ICP-MS) is a
frequently used and most preferred technique for elemental and
isotopic analysis as it combines the remarkable characteristics of
the ICP for atomization and ionization with sensitivity and selectivity
of mass spectrometry. The most common sample introduction
method for ICP-MS is the pneumatic nebulization of
solution. Although it is simple and offers good stability, sample
introduction is inefficient as the sample introduced into plasma
is only 1–3%. Hence, efforts have been made to couple alternative
sample introduction systems, to ICP-MS to extend its application
range. Vapor generator (VG) is one such system that is currently
employed in ICP-MS