This disclosure is directed to an improved dental floss and a method of making it. The improved dental floss comprises a plurality of fibers, e.g., nylon fiber bonded by a non-wax coating and in which there is dispersed various therapeutic agents which are active to remove the bacteria media that promotes bacterial growth about the teeth and mouth. The disclosure is also directed to a method for forming such dental floss in a manner which permits various therapeutic agents to be simultaneously bonded in the coating of the fibers.