This is achieved by monitoring the changes in the reflected interference patterns caused by the increase in the optical thickness of the biomolecular layer (Özkumuret al., 20 09; Albrecht et al., 2010; Kurihara et al., 2012). Sensing systems based on reflectrometric interference spectroscopy have been applied for the detection of biomarkers, food contaminants, etc., either in single or multi-analyte format.