Anemia is a frequent problem in patients with chronic kidney disease (CKD) who are not yet receiving dialysis and can lead to major health complications is left untreated. The successful management of these patients entails repletion of iron stores, often through use of intravenous iron, particularly in patients receiving erythropoietin therapy. To encourage patient compliance with anemia management protocols, the nephrology nurse can play a key role in patient education in reducing barriers to proper management and in raising the awareness of the benefits of treating this condition.