S. aureus, Corynebacterium sp., MRSA 49, MRSA 50 and P. acnes were inhibited by mānuka honey after treatment with catalase enzyme with diameters of the inhibiton zones of 20.33 ± 0.58, 24.00 ± 1.00, 23.33 ± 2.08, 20.33 ± 0.58 and 11.33 ± 0.58 mm., respectively.