tions due to higher encapsulation efficiency (above 45%), increased stability against its melting, and ease of pro- duction. However, liposomes smaller than 50 nm in di- ameter proved to be effective for the simultaneous en- capsulation of hydrophilic compounds (inside the vesicle) and hydrophilic antioxidants (α-tocopherol) solubilized in the hydrophobic portion of the lipid bilayer [36]. Fer- reira et al. [37] reported that LUVs are very stable phys- ically, when kept at 4˚C showing no change of mean di- ameter after 5 days, when stored at ambient temperature they show an increase in average diameter of 10 % at the end of same time. The LEC showed higher encapsulation efficiency, dif- fering significantly (p ≤ 0.05), from the other samples. Priprem et al. [34] prepared liposomes containing quer- cetin (a flavonoid) from egg phosphatidylcholine/cho- lesterol (2:1) and obtained encapsulation efficiency of 60% to 80%. Takahashi et al. [33] prepared liposomes using commercial lecithin for encapsulation of curcumin (polyphenolic pigment), in order to increase the bioavai- lability and functionality of this feed. These authors re- ported that the results showed greater gastrointestinal absorption and significantly higher antioxidant activity in plasma for curcumin encapsulated in liposomes, and en- capsulation efficiency of 68%.