In terms of numbers, the Yotsuba Family were plainly outnumbered by the Saegusa and Ichijou Families. Yet, their combat prowess were comparable. In 1 on 1 confrontations, the Yotsuba would have the advantage. Despite their limited numbers, they were more than capable of becoming the counter-terrorism trump card of the government and carry out any action that went beyond the reach of the law that the government needed. In terms of black ops and assassinations, none among the "Numbered Families" could match the Yotsuba Family.