However, BV administration was reported to stimulate
the function of immune system [12] and to affect the
release of cortisol production which is known as natural
anti-inflammatory agent [13]. Melittin which is the major
component of BV was found to suppress inflammation by
inhibiting phospholipase (PLA) enzymatic activity [14].
This enzyme was abundantly released in severe
inflammatory disorders and actively found to cause
tissue and organ degradation which will lead to the loss
of their functions [15]. Furthermore, melittin was also
found to block the production of neutrophil superoxide
[16].
A large number of studies have been carried out on the
composition of honeybee venom. Much of the basic
identification of compounds, their isolation and the study
of their pharmacological effects of bee venom was done
in the 1950's and 1960's. There are some comprehensive
summaries in [17] which cover the morphology of the
venom apparatus, the collection of venom, the
pharmacological effects of bee venom and allergies to the
Hymenoptera venom of bees, wasps and ants. [11]
presents a comprehensive account of allergies to
honeybee and other Hymenoptera venoms. [18], [19],
[20], [21] give a very good overview of its composition,
However, BV administration was reported to stimulatethe function of immune system [12] and to affect therelease of cortisol production which is known as naturalanti-inflammatory agent [13]. Melittin which is the majorcomponent of BV was found to suppress inflammation byinhibiting phospholipase (PLA) enzymatic activity [14].This enzyme was abundantly released in severeinflammatory disorders and actively found to causetissue and organ degradation which will lead to the lossof their functions [15]. Furthermore, melittin was alsofound to block the production of neutrophil superoxide[16].A large number of studies have been carried out on thecomposition of honeybee venom. Much of the basicidentification of compounds, their isolation and the studyof their pharmacological effects of bee venom was donein the 1950's and 1960's. There are some comprehensivesummaries in [17] which cover the morphology of thevenom apparatus, the collection of venom, thepharmacological effects of bee venom and allergies to theHymenoptera venom of bees, wasps and ants. [11]presents a comprehensive account of allergies tohoneybee and other Hymenoptera venoms. [18], [19],[20], [21] give a very good overview of its composition,
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