It’s at this point that the experimental evidence becomes indirect and weak
for lack of information. At face value, there are four obvious candidates for the specific substrates of
PP2A-B55. First and foremost are Wee1 and Cdc25, but it’s quite unclear that these are exclusively
dephosphorylated by PP2A-B55. Next, Greatwall itself appears to be a target, directly or indirectly, of
PP2A-B55, since it becomes phosphorylated in response to added to phosphorylated ENSA or ARPP19
It’s at this point that the experimental evidence becomes indirect and weak
for lack of information. At face value, there are four obvious candidates for the specific substrates of
PP2A-B55. First and foremost are Wee1 and Cdc25, but it’s quite unclear that these are exclusively
dephosphorylated by PP2A-B55. Next, Greatwall itself appears to be a target, directly or indirectly, of
PP2A-B55, since it becomes phosphorylated in response to added to phosphorylated ENSA or ARPP19
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