Results from the first large-scale survey of floating natural (NMD) and anthropogenic (AMD) debris (>2 cm) in the central and western part of the Mediterranean Sea are reported. Floating debris was found throughout the entire study area with densities ranging from 0 to 194.6 items/km2 and mean abundances of 24.9 AMD items/km2 and 6.9 NMD items/km2 across all surveyed locations. On the whole, 78% of all sighted objects were of anthropogenic origin, 95.6% of which were petrochemical derivatives (i.e. plastic and styrofoam). Maximum AMD densities (>52 items/km2) were found in the Adriatic Sea and in the Algerian basin, while the lowest densities (