In the course of observation for 4 h. after castor oil administration, all the mice in control group produced copious
diarrhoea. Pretreatment of mice with the different doses of ACR caused a significant dose dependent decrease in the
frequency of purging (reduction of number of wet stools and total no of stools). ACR showed 30.36 %, 37.90 %,
45.45 % inhibition of diarrhoea at doses of 125 mg/kg, 250 mg/kg and 500 mg/kg while Loperamide at dose of 2