Therefore, an important balance exists between the beneficial and harmful effects of IL-1. It can negatively impact the vascular, endocrine, connective tissue, immune, haematopoietic, and central nervous systems,
rendering it an important therapeutic target in a number of pathological conditions including rheumatoid arthritis, atherosclerosis, diabetes mellitus type I, inflammatory bowel disease and other autoimmune disorders, Alzheimer's disease, leukaemia, and solid tumors