In October 2005, it was announced that the Auntie Anne's corporate headquarters would be relocated from the town of Gap to downtown Lancaster. The former site of the Lancaster Post Office was purchased for $7 million by Auntie Anne's, Inc. The building itself was constructed in 1927, and stands at three stories tall on about 1.5 acres (6,100 m2). The building maintains the original 1920s features such as brass doors, high ceilings, and skylights. The Lancaster Post Office was listed on the National Register of Historic Places in 1982.
In November 2010, FOCUS Brands acquired Auntie Anne's. Auntie Anne's began a partnership with Food Donation Connection in 2011, matching stores throughout the country with local hunger relief organizations to donate extra pretzel products. In 2013, Anne and Auntie Anne's was featured in "Food Court Wars".