The oils were well tolerated, with no deaths during the study,
and the mice were in apparent good health. Previous studies in
C57BL/6J mice have shown that the inclusion of FO in the diet is
accompanied by weight loss (44, 45). However, in the present
study, higher EPA-rich CO and FO intakes (COH and FOH), as
part of a 10% of energy from fat diet, were associated with body
weight gain, and no differences were observed in liver weight.
These findings are more consistent with previous studies in
which FO was fed to mice (46, 47) and rats (48) as part of lowfat
regimes, which showed no major differences in body and
liver weight.