Duality of Interest. This is an independent research study not supported by pharmaceutical companies. P.L. has received travel grants for scientific meetings from Sanofi, Medtronic, and Theras Group. F.P. has received honoraria for speaker fees and/or travel grants from Sanofi, Eli Lilly & Co., Bristol-Myers Squibb, and Merck & Co. G.B.B. received honoraria from sanofi-aventis and Eli Lilly & Co. for scientific advising and consulting. C.G.F. has served on scientific advisory panels for Sanofiand received speaker fees and/or travel grants from Bristol-Myers Squibb, Merck & Co., and The Menarini Group. No other potential conflicts of interest relevant to this article were reported.