The first ZIKV outbreak in Yap State was unexpected and demonstrated the potential for ZIKV emergence. The second outbreak in French Polynesia was also unexpected and was associated for the first time with severe neurologic disease. From French Polynesia, ZIKV spread in the Pacific and imported cases were reported on several continents. In 2015, ZIKV emerged in the Americas and, as in French Polynesia, appears to be associated with severe neurologic disease. An outbreak has also been reported in the Cape Verde Islands (Africa). The emergence of ZIKV in areas with cocirculation of other flaviviruses will make diagnosis based on clinical and epidemiological grounds difficult and unreliable. The emergence of ZIKV in the Pacific, the Americas, and Africa underscores the potential for ZIKV to spread globally as DENV and CHIKV have done. The future of ZIKV is unpredictable, but its recent spread confirms that ZIKV is following in the path of CHIKV and DENV (40). The severe disease associated with ZIKV in French Polynesia and Brazil, however, suggests that this virus will become a very serious global public health problem.