Define which protocol, source, destination and port are denied:
Router(config)#access-list 101 deny tcp 10.0.0.0 0.255.255.255 187.100.1.6 0.0.0.0 eq 21
Router(config)#access-list 101 deny tcp 10.0.0.0 0.255.255.255 187.100.1.6 0.0.0.0 eq 20
Router(config)#access-list 101 permit ip any any Apply this ACL to an interface:
Router(config)#interface Fa0/1
Router(config-if)#ip access-group 101 out
Notice that we have to explicit allow other traffic (access-list 101 permit ip any any) as there is an “deny all” command at the end of each ACL.
As we can see, the destination of above access list is “187.100.1.6 0.0.0.0″ which specifies a host. We can use “host 187.100.1.6″ instead. We will discuss wildcard mask later.