Upon fibroin or sericin stimulation, we observed a strong upregulation of c Jun. Such upregulation was even more pronounced as the cells are situated closer to the wound border of the wound scratch(Figure S4A, B, C). Interestingly, the addition of LY294002 ,SP600125 and PD98059 prevented the fibroin stimulation of cJun(Figure 7 B. Similarly, LY294002, SP600125, and PD98059 blocked sericin induced cJun expression(Figure 7C). These data suggest that cell migration stimulation of fibroin and sericin is directly related to the expression of cJun at the wound healing edge