Abstract
Up to 90% of pregnant women experience nausea and vomiting. When prolonged or severe, this is known as
hyperemesis gravidarum (HG), which can, in individual cases, be life threatening. In this article the aetiology, diagnosis
and treatment strategies will be presented based on a selective literature review. Treatment strategies range from
outpatient dietary advice and antiemetic drugs to hospitalization and intravenous (IV) fluid replacement in persistent
or severe cases. Alternative methods, such as acupuncture, are not yet evidence based but sometimes have a
therapeutic effect.
In most cases, the condition is self limiting and subsides by around 20 weeks gestation. More severe forms require
medical intervention once other organic causes of nausea and vomiting have been excluded. In addition, a
psychosomatic approach is often helpful.
In view of its potential complexity, general practitioners and obstetricians should be well informed about HG and
therapy should be multimodal.