Within 7 days of administration of afoxolaner chewable tablets, flea counts on dogs were reduced by 99.3 %.
By one month post-treatment, total flea counts on dogs were reduced by 99.9 %, with 97.3 % (36/37) of the dogs being
flea free. Following the second dosing on study day 28–30, total on-dog flea burden was reduced by 100 % on days
40–45 and 54–60. On day 0, the traps collected a geometric mean of 18.2 fleas. Subsequent reductions in emerging flea
populations were 97.7 and 100 % by days 28–30 and 54–60, respectively. There were 515 total fleas (Ctenocephalides
felis felis) collected in the intermittent light flea traps on day 0, and 40.4 % of those fleas displayed visual evidence
of having fed. Seven days after initial treatment, only 13.1 % of the fleas contained blood and by day 14 only
4.9 % of the fleas collected in traps displayed evidence of having fed. On day 0, prior to treatment, 60 % of the
unfed fleas collected in intermittent-light flea traps were females, but by days 28–30, unfed males accounted for
78 % of the population.