To conclude, in community-dwelling elderly participants from the Three-City Study, there was some heterogeneity in the association between lipids and future CHD according to the lipid-lowering treatment received at baseline. In those who did not receive any lipid-lowering treatment, LDL cholesterol, non-HDL cholesterol, ApoB100, ApoB/ApoA1, and LDL/HDL cholesterol ratios were all predictors of CHD over 4 years, independently of other traditional risk factors and hs-CRP. Among those who received statin therapy (11.5% of the study cohort), the same lipid parameters were predictors of CHD, but in general with greater strength. In those who were on fibrates (13% of the study cohort), only triglycerides were independent predictors of CHD.
To evaluate associations of standard lipids and apolipoproteins with incident coronary heart disease (CHD) in older adults according to lipid-lowering treatment (LLT) in the primary prevention setting.