We were able to detect a greater UGIB risk among users
of higher doses of NSAIDs, users of long-acting drugs, and
users of more than one NSAID, results which are consistent
with those described in previous studies [13]. Interestingly,
we observed a higher risk within the first 30 days of
treatment with NSAIDs. The reduction in the relative risk
observed with continuous treatment beyond that point may
be interpreted as an attrition for susceptible people [22], but
an adaptive mechanism of the gastrointestinal mucosa may
also have a role