Likewise, CYP2A6 was also proven to be involved in the oxidization of APAP, to its primary non-toxic metabolite(3-OH-APAP)andsecondarytoxicmetabolite(NAPQI),where the rate of formation of 3-OH-APAP was observed to be 3 times faster than NAPQI, thus indicatively representing the significant role of CYP2A6 inAPAP overdose