The obtained data by the two methods were compared by pairedt-Test. The results show that there are no significant difference(P > 0.05) between TEPA-MP dSPE-RP-HPLC method and UFLC-MS/MS method, which reveals that the quantitation of the proposed TEPA-MP dSPE-RP-HPLC method is comparable with that of UFLC–MS/MS method.The proposed method can be applied to the analysis of wine samples with satisfactory results.