6. KINETICS
6.1 Absorption by route of exposure
Ethambutol hydrochloride, following a single oral dose
of 25 mg/kg of body weight, attains a peak of up to 5 œg/mL
in serum within 4 hours after administration and is less than
1 ug/ml by 24 hours. When the drug is administered daily for
longer periods of time at this dose, serum levels are
similar.
About 80% of an oral dose of ethambutol is absorbed from the
gastro-intestinal tract, and the remainder appears in the
faeces unchanged. Absorption is not significantly impaired by
food.
(Reynolds, 1993)