Cell growth factors and bioactive drugs can be not only directly encapsulated into GMs during preparation , but also grafted or coated on surface of GMs. Therefore, tetracycline hydrochloride (TH) loaded GMs were fabricated by an emulsion cross-linking method, followed by integrating into OAlg-CMCS hydrogels to produce a composite gel dressing. The effects of varying the ratio of microspheres on gelation time, microstructure, morphology, equilibrium swelling, compressive modulus and degradation in vitro were